Global assessment of integrated stress response in CF patients lung explants and organoids. Global assessment of integrated stress response in CF patients lung explants and organoids

Freshly acquired lung tissue from CF patients with advanced disease and prolonged exposure to pathogenic microorganisms display a clear molecular signature of activated unfolded protein response (UPR) and chronic inflammation. Overall design: RNA sequencing and gene expression analysis of CF lung explants and organoids (ileum and colon)