VTRNA2-1 binds PKR

Several cellular RNA species act as PKR inhibitors, supporting general protein translation. For instance, VTRNA2-1 (ns886, miR-886), a noncoding vault RNA that is transcribed by RNA polymerase III,, takes part in host cell regulation of PKR activity. Its two conformers bind to PKR and can either inhibit or weakly enhance PKR dimerization and activation (Lee et al, 2011; Jeon et al, 2012; Calderon & Conn, 2015). VTRNA2-1 activity has been implicated in pathological progress of oncogenesis (Lei J et al. 2017; Gao W et al. 2022) while several studies identified a tumor suppressive role of VTRNA2-1 (Fort RS et al. 2018, 2019; Yang R et al. 2021).

数种细胞RNA物种充当PKR抑制剂，从而支持蛋白质的总体翻译。例如，VTRNA2-1（ns886，miR-886），一种由RNA聚合酶III转录的非编码囊状RNA，参与宿主细胞对PKR活性的调控。其两种构象可以与PKR结合，既可以抑制也可以弱化PKR的二聚化和激活（Lee等人，2011；Jeon等人，2012；Calderon与Conn，2015）。VTRNA2-1的活性被认为与肿瘤发生发展的病理进程有关（Lei J等人，2017；Gao W等人，2022），而多项研究亦确认了VTRNA2-1在肿瘤抑制方面的作用（Fort RS等人，2018，2019；Yang R等人，2021）。