Assessment of cure by benznidazole (Bz) and posaconazole (Ps), administered in monotherapy or sequential combinations, in a murine model of Trypanosoma cruzi infection1.

1Swiss female (n = 10) weight 20 to 24 g were inoculated with 5×103 trypomastigotes (Y strain).Treatment was initiated at 4th day after inoculation followed by 10 or 20 daily doses and it was being orally administered.2FBE – fresh blood examination performed before and after cyclophosphamide immunossupression.3PCR assay was performed in the 1st and 6th month after treatment.4mpk – milligrams/kilogram/day.5All mice died before 30 days of infection.6All mice had positive results in fresh blood examination.