Lung expression of human ACE2 sensitizes the mouse to SARS-CoV2 infection

Development of nonclinical mouse models that show some COVID-19 symptoms such as pneumonia and viral load in targeted tissues such as lung will facilitate the preclinical studies and our understanding of pathogenesis and host responses. Overall design: 6 paired end samples with 3 controls as indicated; The mice inoculated Ad5-hACE2 or Ad5-empty and infected SARS-CoV2 at each time point.