Autophagy impairments in directly reprogrammed neurons in patients with idiopathic Parkinson's disease

Protein degradation impairment is strongly suspected to play a role in idiopathic Parkinson's disease (PD). However, current tools and models are lacking to study such disease associated phenotypes across the PD patient population. Here, we generate functional induced dopaminergic neurons (iDANs) directly reprogrammed from adult dermal fibroblasts of patients with PD to investigate intra-neuronal autophagy alterations. Overall design: RNA sequencing of fibroblasts and induced neuronal cells from persons with and without Parkinsons Disease