Table1_A report on SARS-CoV-2 first wave in Ecuador: drug consumption dynamics.docx

Introduction: The first COVID-19 wave in Ecuador started in March 2020 and extended until November. Several types of drugs have been proposed as a potential treatment during this period, and some affected people have self-medicated.Method: A retrospective study was conducted with 10,175 individuals who underwent RT-PCR tests for SARS-CoV-2 from July to November 2020. We compared the number of positive and negative cases in Ecuador with symptoms and drug consumption. The Chi-square test of independence compared clinical and demographic data and PCR test results. Odds ratios analyzed drug consumption dynamics.Results: Of 10,175 cases, 570 were positive for COVID-19, while 9,605 were negative. In positive cases, there was no association between the RT-PCR result and sex, age, or comorbidities. When considering demographic data, Cotopaxi and Napo had the highest rates of positive cases (25.7% and 18.8%, respectively). Manabí, Santa Elena, and Guayas regions had fewer than 10% positive cases. The Drug consumption dynamic analysis showed that negative COVID-19 cases presented higher drug consumption than positive cases. In both groups, the most consumed medication was acetaminophen. Acetaminophen and Antihistamines had higher odds of consumption in positive PCR cases than in negative. Symptoms like fever and cough were more related to positive RT-PCR results.Conclusion: The first COVID-19 wave in Ecuador has affected the provinces differently. At a national level, the consumption of drugs has been highly associated with self-medication.

引言：厄瓜多尔首波COVID-19疫情始于2020年3月，持续至11月。在此期间，多种药物被提出作为潜在的治疗方案，部分受影响者已自行用药。研究方法：本研究采用回顾性研究方法，对2020年7月至11月期间接受SARS-CoV-2 RT-PCR检测的10,175名个体进行了分析。我们比较了厄瓜多尔阳性与阴性病例的症状及药物使用情况。通过卡方检验独立性，对临床和人口统计数据以及PCR检测结果进行了比较。通过计算比值比分析了药物使用动态。结果：在10,175个病例中，570例确诊为COVID-19，9,605例为阴性。在确诊病例中，RT-PCR结果与性别、年龄或合并症之间无关联。在考虑人口统计数据时，科托帕希和纳波地区的阳性病例率最高（分别为25.7%和18.8%），而马纳比、圣埃莱娜和瓜亚斯地区的阳性病例率均低于10%。药物使用动态分析显示，阴性COVID-19病例的药物使用量高于阳性病例。在两组中，最常使用的药物为扑热息痛。扑热息痛和抗组胺药在阳性PCR病例中的使用几率高于阴性病例。发热和咳嗽等症状与阳性RT-PCR结果更为相关。结论：厄瓜多尔首波COVID-19疫情对各省的影响各异。在全国层面，药物消耗与自我用药高度相关。