Applications of C–H Functionalization Logic to Cyclobutane Synthesis

The
application of C–H functionalization logic to target-oriented
synthesis provides an exciting new venue for the development of new
and useful strategies in organic chemistry. In this article, C–H
functionalization reactions are explored as an alternative approach
to access pseudodimeric cyclobutane natural products, such as the
dictazole and the piperarborenine families. The use of these strategies
in a variety of complex settings highlights the subtle geometric,
steric, and electronic effects at play in the auxiliary guided C–H
functionalization of cyclobutanes.