Carboiodination Catalyzed by Nickel

A novel
nickel-catalyzed cycloisomerization reaction forming a
new carbon–carbon bond while preserving the carbon–halogen
bond has been developed. A cheap and readily available Ni-catalyst
is employed to generate nitrogen containing heterocycles in good to
excellent yields and the procedure is readily scalable. The more readily
available aryl bromides were also cyclized with the addition of potassium
iodide to generate the respective alkyl iodides. A rare dual ligand
system employing a bisphosphine and bisphosphine monoxide was used
to achieve enantioenriched products.