Estrogen-related receptor ? agonist DY131 ameliorates lipopolysaccharide-induced acute liver injury

DY131 is a pharmacological agonist of the orphan receptor estrogen-related receptor (ERR) ? which plays a crucial role in regulating energy generation, oxidative metabolism, cell apoptosis, inflammatory responses, etc. However, its role in acute liver injury is unknown. In the study, we evaluated the effect of DY131 on lipopolysaccharide (LPS)-induced liver injury. Transcriptomics analysis revealed that the dysregulated pathways associated with inflammation and metabolism were significantly reversed by DY131 in LPS-treated mice, providing more evidence in favor of the protective effect of DY131 against LPS-induced liver injury. Overall design: Mice were pretreated with DY131 through intraperitoneal injection at a dose of 5 mg/kg/day for three days prior to LPS challenge (10mg/kg). 24?hours later, they were anesthetized and sacrificed. Blood and liver tissues were collected for further studies.