Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand
收藏Protein Data Bank Japan2023-11-08 更新2026-03-21 收录
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Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand Descriptor: 1,2-ETHANEDIOL, 5-bromo-N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)-2-methoxybenzenesulfonamide, Bromodomain-containing protein 4, ... Authors: Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. Deposit date: 2015-09-23 Release date: 2016-01-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
创建时间：
2015-09-23
