Molecular signatures of the Eagle effect induced by the artificial siderophore conjugate LP-600 in E. coli

We investigated a paradoxical re-growth of E. coli upon treatment of a novel siderophore-conjugate, LP-600, at concentrations 16-32 times above the minimum inhibitory concentration (MIC).Transcriptome analysis revealed that LP-600 induced the expression of genes involved in SOS response and e14 prophage upon regrowth conditions. Overall design: E.coli mRNA profiles of siderophore-conjugate treatments at different concentrations and growth phases