Chemical, geometric and kinetic/thermodynamic parameters used in the model.

[a]average concentration found in human blood.[b]protein radius calculated as if each protein were spherical.[c]starting concentration in the simulation.[d]association rate constant; see Materials and Methods section for details.[e]dissociation rate constant: see Materials and Methods section for details.[f]equilibrium constant (KA = kon/koff).[g]ideal number of binding sites on the nanoparticle surface for the protein i.[h]see Materials and Methods section for details.[i]average values for a healthy adult human [18]–[20].