Top novel associations (P≤1×10−6) identified using SNP genotype and estimate of local African versus European ancestry.

Global ancestry is included in the model for both methods.1Coordinates are on NCBI build 36.1.2Average frequency for the reference allele across all available African American CARe samples.3Direction of the effect given for the reference allele; SE, standard error.4P-values are scaled using genomic control.5Z-score for the SNP genotype information. A Z-score >0 means that the trait (or the risk to develop the disease) increases with the number of copies of reference alleles.6Z-score for the local ancestry estimate information. A Z-score >0 means that the trait (or the risk to develop the disease) increases with the number of copies of European chromosomes.7Genes in a 200 kb window.