Palladium-Catalyzed Synthesis of Indanone via C–H Annulation Reaction of Aldehydes with Norbornenes

A novel
methodology for the synthesis of indanone derivates has
been developed. The palladium-catalyzed annulation reaction of o-bromobenzaldehydes with norbornene derivatives is achieved
through extremely concise reaction processes. The indanone skeleton
was established directly via C–H activation of the aldehyde
group under a mild reaction condition. This method is simple and practical,
which simplified the traditional synthesis method for the rapid construction
of indanone.