Digital twin mathematical models suggest individualized hemorrhagic shock resuscitation strategies
收藏DataONE2024-05-21 更新2024-06-08 收录
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Background: Optimizing resuscitation to reduce inflammation and organ dysfunction following human trauma-associated hemorrhagic shock is a major clinical hurdle. This is limited by the short duration of pre-clinical studies and the sparsity of early data in the clinical setting.
Methods: We sought to bridge this gap by linking preclinical data in the porcine model with clinical data from patients from the Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) study via a three-compartment ordinary differential equation model of inflammation and coagulation.
Results: The model accurately predicts physiologic, inflammatory, and laboratory measures in both the porcine model and patients, as well as the outcome and time of death in the PROMMTT cohort. Model simulation suggests that resuscitation with plasma and red blood cells outperformed resuscitation with crystalloid or plasma alone, and that earlier plasma resuscitation reduced injury severity and increased survival..., , , # Data from: Digital twin mathematical models suggest individualized hemorrhagic shock resuscitation strategies
This README file was generated on 2024-05-18 by Jeremy Cannon.
GENERAL INFORMATION
1\. Title of Dataset: Data from: Digital twin mathematical models suggest individualized hemorrhagic shock resuscitation strategies
2\. Author Information
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A. Principal Investigator Contact Information
Name: Jeremy Cannon
Institution: University of Pennsylvania
Address: Philadelphia, PA USA
Email: jeremy.cannon@pennmedicine.upenn.edu
B. Associate or Co-investigator Contact Information
Name: Yoram Vodovotz
Institution: University of Pittsburgh
Address: Pittsburgh, PA USA
Email: vodovotzy@upmc.edu
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3\. Date of data collection (single date, range, approximate date):
A) Animal Data: 2009
B) Human Data: 2009-2010
C) Modeling Data: 2018-2020
4\. Geographic location of data collection:
A) Animal Data: Oregon Health and Science University, Portland, OR, USA
B) Hu...
创建时间：
2025-07-31
