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Male summary statistics from "Role of X chromosome and dosage compensation mechanisms in complex trait genetics"

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Zenodo2025-04-04 更新2026-05-26 收录
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Full male summary statistics generated in "Role of X chromosome and dosage compensation mechanisms in complex trait genetics". For UK biobank (UKB), GWAS were performed using BOLT-LMM v2.3.2. Analyses were performed on a) full samples for autosomes and the X chromosome; b) samples downsized by half in the non-PAR region of the X chromosome. The files contain the following columns: SNP: rs number or ID string CHR: chromosome BP: base pair position mapped to assembly GRCh37 GENPOS: genetic position either from bim file or interpolated from genetic map ALLELE1: first allele in bim file (usually the minor allele), used as the effect allele ALLELE0: second allele in bim file, used as the reference allele A1FREQ: frequency of first allele F_MISS: frequency of first allele CHISQ_LINREG: standard linear regression chi-square statistics P_LINREG: standard linear regression p-value BETA: effect size from BOLT-LMM approximation to infinitesimal mixed model SE: standard error of effect size CHISQ_BOLT_LMM_INF: infinitesimal mixed model association test chi-square statistics P_BOLT_LMM_INF: infinitesimal mixed model association test p-value CHISQ_BOLT_LMM: non-infinitesimal mixed model association test chi-square statistics P_BOLT_LMM: non-infinitesimal mixed model association test p-value For FinnGen R10 (FG), GWAS were performed using REGENIE v2.2.4 pipeline. The files contain the following columns: #chrom: chromosome pos: base pair position mapped to assembly GRCh38 ref: reference allele alt: alternative allele pval: analysis p-value mlogp: -log10(p-value) beta: effect size of alternate allele sebeta: standard error of effect size af_alt: allele frequency of the alternative allele

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2025-04-03
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