Dose-responsive mRNA and microRNA profiles in mahi-mahi (Coryphaena hippurus) larvae exposed to Deepwater Horizon oil

Genome-wide mRNA and microRNA profiles of 48 hpf mahi-mahi (Coryphaena hippurus) larvae after treated with a series concentrations of slick as well as source oil were generated by next generation sequencing, in triplicate, using Illumina NextSEQ v2. All reads were pooled and assembled de novo using Trinity (version 2.2.0). Statistical bioinformatic analysis was further conducted by DAVID and Ingenuity Pathway Analysis to reveal dose-response biological effects of oil exposure.