Similar survival of lethal challenge by LVS-vaccinated WT and IL-23 KO mice.

aIn experiment 1 (Exp. 1), WT C57BL/6J mice or IL-23 KO mice (either p19M KO or p19G KO mice, as indicated) were infected either with 105–106 ID or 102 IN LVS. One month later, when primary infection was cleared, surviving mice were given a secondary high dose challenge of 2×106 IP or 8×107 LVS IN. Naïve control mice treated with PBS ID or IN were challenged as indicated IN or IP, where all mice died.
bExp. 2, mice were given a primary vaccination of 2×102 or 2×103 IN and challenged with 2×106 IP. The average time to death (TTD) of those mice that died within a group is also shown, as well as the range of the days of death. Groups where all the mice succumbed on the same day are given a range of (N/A). Data are representative of three experiments of similar design and outcome.
Similar survival of lethal challenge by LVS-vaccinated WT and IL-23 KO mice.