Efficacy of sindilizumab combined with FLOT4 regimen in neoadjuvant therapy for locally advanced gastric cancer and the correlation between circulating tumor DNA, tumor immune microenvironment, intestinal microbiome and therapeutic efficacy: a single-arm, single-center prospective study

Interventions: NA:sintilimab combined with FLOT4 regimen
Primary outcome(s): Pathological complete response rate;ctDNA changes in circulating tumors before and after neoadjuvant therapy and its correlation with neoadjuvant therapy (FLOT4 combined with sindilizumab)
Study Design: Single arm