TODAY2 Control Echocardiogram Sample Data Collection Study

The TODAY (Treatment Options for Type 2 Diabetes in Adolescents and Youth) study was a multi-center randomized clinical trial (2004-2011). Youth aged 10-17 years diagnosed with type 2 diabetes (T2D) for less than 2 years were enrolled. The trial compared the efficacy of three treatment arms: (1) metformin alone, (2) metformin plus rosiglitazone, and (3) metformin plus an intensive lifestyle intervention. The TODAY trial concluded in February 2011 and was followed by TODAY2 (2011-2020), an observational longitudinal study to continue follow-up of the TODAY cohort to document the progression of diabetes and its complications and related comorbidities.

In the last year of the TODAY study, the cohort was assessed by echocardiography. A follow-up echocardiogram was completed 5 years later during the TODAY2 study. During TODAY2, the study also collected comparative echocardiogram control data in individuals without diabetes and hypertension, and also performed a one-time collection of data and blood for storage of serum and plasma in these consented control participants.