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Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA4)

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Protein Data Bank Japan2024-11-13 更新2026-04-19 收录
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Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA4) Descriptor: (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[[9-[(2~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7~{H}-purin-6-yl]amino]propyl]amino]-2-azanyl-butanoic acid, ACETATE ION, MAGNESIUM ION, ... Authors: Bedi, R.K, Etheve-Quelquejeu, M, Caflisch, A. Deposit date: 2023-07-19 Release date: 2023-11-08 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The catalytic mechanism of the RNA methyltransferase METTL3. Elife, 12, 2024
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2023-07-19
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