Lineage and ecology define liver tumor evolution in response to treatment. Lineage and ecology define liver tumor evolution in response to treatment

Single-cell transcriptome-based strategy to determine the evolutionary trajectories of longitudinal tumor biopsies from liver cancer patients by measuring cellular lineage and ecology. Our study provides a framework for monitoring tumor evolution in response to therapeutic intervention. Overall design: scRNA seq was performed on 31 longitudinal samples collected from 11 liver cancer patients undergoing immunotherapy treatment. *** Due to patient privacy concerns, patient data will be submitted to dbGaP. ***