Hair and plasma cortisol throughout the first three years of development in infant rhesus macaques, Macaca mulatta

Cortisol expression has been demonstrated to have variation across development in rhesus macaques (Macaca mulatta). There exists contradictory evidence for the nature of this change, and age at which it occurs, across biological sample types. Consequently, we lack a cohesive understanding for cortisol concentrations across the development of a major human health translational model. We examined hair cortisol concentrations over the first three years of life for 49 mother-reared infant macaques from mixed-sex outdoor units at the California National Primate Research Center. For 48 of these subjects at infancy, one year, and two years, we obtained plasma cortisol samples for: response to a stressor, adjustment to prolonged stress, and response to dexamethasone injection. Hair cortisol concentrations decreased dramatically between three and ten months, followed by relative stability up to the final sampling event at around 34 months of age. Plasma cortisol showed within-year consistency, a..., These data were collected at the California National Primate Research Center from hair and plasma samples obtained from infants and juveniles housed in large outdoor mixed-sex social units., Applications used are: *.csv reader, such as Microsoft Excel or LibreOffice Calc and R Software Environment., # Hair and plasma cortisol throughout the first three years of development in infant rhesus macaques, Macaca mulatta

Alexander J. Pritchard, John P. Capitanio, Laura Del Rosso, Brenda McCowan, Jessica Vandeleest

Developmental Psychobiology (https://doi.org/10.1002/dev.22437)

We have included 2 data files and 2 R code files. The R code functions to read in the files and assembles output that was used to generate the figures and tables in the manuscript.

## Description of the data and file structure

Two data files:
Plasma_CORT.csv has five data columns: a sequential subject ID, condition (which is a combined code of sample type and year of sample), CORT concentrations in ug/dL, sample, and year.

FINAL_Hair_CORT.csv has nine data columns: a sequential subject ID, sampling event (note, each ID was only subject to 1 BBA and 5 round-up collection events), Date of collection, CORT concentrations in pg/mg (the single NA was, as referenced in the manuscript: \"was erroneously not rerun, des...