Associations of five SNPs with parameters of glycaemia, insulin sensitivity, insulin secretion and proinsulin-to-insulin conversion (N = 1782).

Data represent means ± SEM for each genotype.
aAlleles are listed in order of glycemic effect (known glucose-raising allele on the right) and the additive model was applied for all calculations. For the statistical analyses data were log-transformed.
bPlasma glucose levels, ISI and HOMA-IR were adjusted for age, sex and BMI.
cAll other parameters were adjusted for age, sex, BMI and ISI.
dP values with nominal significance (<0.05) are indicated with bold, P values significant after correction for multiple testing (<0.0042) are indicated with bold and italic.
eInsulin sensitivity index as proposed by Matsuda and de Fronzo.
fHomeostasis model assessment index for insulin resistance.