Associations of five SNPs with parameters of glycaemia, insulin sensitivity, insulin secretion and proinsulin-to-insulin conversion (N = 1782).

Data represent means ± SEM for each genotype. aAlleles are listed in order of glycemic effect (known glucose-raising allele on the right) and the additive model was applied for all calculations. For the statistical analyses data were log-transformed. bPlasma glucose levels, ISI and HOMA-IR were adjusted for age, sex and BMI. cAll other parameters were adjusted for age, sex, BMI and ISI. dP values with nominal significance (<0.05) are indicated with bold, P values significant after correction for multiple testing (<0.0042) are indicated with bold and italic. eInsulin sensitivity index as proposed by Matsuda and de Fronzo. fHomeostasis model assessment index for insulin resistance.