The application value of metagenomic next-generation sequencing in community-acquired purulent meningitis after antibiotics intervention

Bacteria account for nearly one-third of the causes of community-acquired central nervous system infections, and the traditional diagnostic methods of such diseases rely on culture results, which is time-consuming, low detection rate and delayed diagnosis and treatment. Since metagenomic next-generation sequencing (mNGS) has the advantages of high timeliness and only detecting microbial trace gene fragments, it has been more widely used in recent years. Based on this, we explored whether the application of cerebrospinal fluid next-generation sequencing is advantageous in patients with community-acquired purulent meningitis, especially in people who have already used antibiotics.