Chitosan Schiff base Ruthenium(III) complexes

Chitosan can be modified chemically by condensation reaction of deacetylated chitosan with aldehydein homogeneous phase. This condensation is carried by primary amine ( NH2) with aldehyde ( CHO)to form corresponding schiff base. The chitosan biopolymer schiff base derivatives are synthesized withsubstituted aldehydes namely 4-hydroxy-3-methoxy benzaldehyde, 2-hydroxy benzaldehyde, and 2-hydroxy-3-methoxy benzaldehyde, becomes a complexing agent or ligand. The Ruthenium(III) complexeswere obtained by complexation of Ruthenium with schiff base ligands and this product exhibits as anexcellent solubility and more biocompatibility. The novel series of schiff base Ruthenium(III) complexesare characterized by Elemental analysis, FT-IR spectroscopy, and Thermo-gravimetric analysis (TGA). Thesynthesized complexes have been subjected to antibacterial study. The antibacterial results indicated thatthe antibacterial activity of the complexes were more effective against Gram positive and Gram negativepathogenic bacteria. These findings are giving suitable support for developing new antibacterial agentand expand our scope for applications.

壳聚糖可通过将脱乙酰化壳聚糖与醛在均相中进行缩合反应进行化学改性。该缩合反应由伯胺（NH2）与醛（CHO）共同驱动，形成相应的席夫碱。以取代醛，如4-羟基-3-甲氧基苯甲醛、2-羟基苯甲醛以及2-羟基-3-甲氧基苯甲醛为原料合成的壳聚糖生物聚合物席夫碱衍生物，成为络合剂或配体。通过将钌与席夫碱配体络合，获得了钌(III)络合物，该产品表现出优异的溶解性和更高的生物相容性。新型席夫碱钌(III)络合物系列通过元素分析、傅里叶变换红外光谱（FT-IR）和热重分析（TGA）进行了表征。合成的络合物已进行抗菌研究。抗菌结果显示，这些络合物的抗菌活性对革兰氏阳性菌和革兰氏阴性菌更为有效。这些发现为开发新型抗菌剂并拓展其应用范围提供了适宜的支持。