Supplementary Material for: Supervised, Self-Administered Tablet-Based Cognitive Assessment in Neurodegenerative Disorders and Stroke

<b><i>Introduction:</i></b> As the population ages, the prevalence of cognitive impairment is expanding. Given the recent pandemic, there is a need for remote testing modalities to assess cognitive deficits in individuals with neurological disorders. Self-administered, remote, tablet-based cognitive assessments would be clinically valuable if they can detect and classify cognitive deficits as effectively as traditional in-person neuropsychological testing. <b><i>Methods:</i></b> We tested whether the Miro application, a tablet-based neurocognitive platform, measured the same cognitive domains as traditional pencil-and-paper neuropsychological tests. Seventy-nine patients were recruited and then randomized to either undergo pencil-and-paper or tablet testing first. Twenty-nine age-matched healthy controls completed the tablet-based assessments. We identified Pearson correlations between Miro tablet-based modules and corresponding neuropsychological tests in patients and compared scores of patients with neurological disorders with those of healthy controls using <i>t</i> tests. <b><i>Results:</i></b> Statistically significant Pearson correlations between the neuropsychological tests and their tablet equivalents were found for all domains with moderate (<i>r</i> &gt; 0.3) or strong (<i>r</i> &gt; 0.7) correlations in 16 of 17 tests (<i>p</i> &lt; 0.05). All tablet-based subtests differentiated healthy controls from neurologically impaired patients by <i>t</i> tests except for the spatial span forward and finger tapping modules. Participants reported enjoyment of the tablet-based testing, denied that it provoked anxiety, and noted no preference between modalities. <b><i>Conclusions:</i></b> This tablet-based application was found to be widely acceptable to participants. This study supports the validity of these tablet-based assessments in the differentiation of healthy controls from patients with neurocognitive deficits in a variety of cognitive domains and across multiple neurological disease etiologies.