Homo sapiens Raw sequence reads. Homo sapiens

NIAID Data Ecosystem2026-05-02 收录

癌症化疗耐药性研究

代谢靶向治疗

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1108914 数据链接链接失效反馈

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The vulnerability of de novo pyrimidine synthesis during chemotherapy, which can be targeted to overcome chemotherapeutic resistance and augment the antitumor efficacy of genotoxic chemotherapy agents.

创建时间：

2024-05-08

Azathioprine Blocks the Aberrantly Elevated Lipid Metabolism and Induces Apoptosis in Glioblastoma [RNA-Seq]

胶质母细胞瘤耐药性

代谢靶向治疗

Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor with poor survival rate and temozolomide (TMZ) has been used as the standard chemotherapy for GBM treatment. However, a large n

NIAID Data Ecosystem60

Table_2_Identification of a glutamine metabolism reprogramming signature for predicting prognosis, immunotherapy efficacy, and drug candidates in bladder cancer.xls

膀胱癌预后

代谢靶向治疗

BackgroundBladder cancer is the most common malignancy of the urinary system. However, patient prognosis and treatment outcomes in bladder cancer are difficult to predict owing to high tumor heterogen

NIAID Data Ecosystem20

Targeting fatty acid metabolism to abrogate differentiation block in pre-leukemia induced by AML1-ETO

白血病分子机制

代谢靶向治疗

To gain the underlying insight into the functional impact of AML1-ETO expressed in HSPCs, RNA-seq was performed on purified LT-HSCs and GMPs from the bone marrow (BM) of both AML1-ETO expressed (AML1/

NIAID Data Ecosystem10

CRISPR/Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH. CRISPR/Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

癌细胞机制

代谢靶向治疗

Unlike most cell types, many cancer cells survive at low extracellular pH (pHe), a chemical signature of tumors. Genes that facilitate survival under acid stress are therefore potential targets for ca

NIAID Data Ecosystem20

Inhibiting MYC-regulated Glutaminase Metabolic Axis is an Effective Synthetic Lethal Approach for Treating Chemoresistant Cancers

卵巢癌耐药性

代谢靶向治疗

Amplification and expression of the MYC oncogene in tumor cells, including ovarian cancer cells correlates with poor responses to chemotherapy. As MYC is not directly targetable, we have analyzed mole

NIAID Data Ecosystem20

Homo sapiens Raw sequence reads. Homo sapiens

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