Functional dissection of MIEN1 trans-regulation provides new evidence for colorectal cancer genome editing-based therapeutics
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https://www.ncbi.nlm.nih.gov/sra/SRP173340
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资源简介：
MIEN1 has been described as a key actor in colorectal cancer (CRC) biogenesis. We have used CRISPR/Cas9 technique to delete the promoter region of MIEN1 in HT-29 CRC cells. RNA-seq experiments revealed that several biological processes related to migration/metastasis were enriched by differentially expressed genes. Genetically modified cells shown decreased migration capacity. Overall design: RNA-seq experiments of WT and genetically modified HT-29 cells.
创建时间：
2020-12-18
