Supporting data for "Machado: open source genomics data integration framework"

Genome projects and multiomics experiments generate huge volumes of data that must be stored, mined and transformed into useful knowledge. All this information is supposed to be accessible and, if possible, browsable afterwards. Computational biologists have been dealing with this scenario for over a decade and have been implementing softwares and databases to succeed in this matter. The GMODs (Generic Model Organism Database) biological relational database schema, known as Chado, is one of the few successful open source initiatives, it is widely adopted and many softwares are able to connect to it.<br>We have been developing an open source software named Machado, a genomics data integration framework implemented in Python, to enable research groups to both store and visualize genomics data. The framework relies on the Chado database schema and, therefore, should be very intuitive for current developers to adopt it or have it running on the top of already existing databases. It has several data loading tools for genomics and transcriptomics data and also for annotation results from tools such as BLAST, InterproScan, OrthoMCL and LSTrAP. There is an API to connect to JBrowse and a web visualisation tool is implemented using Django Views and Templates. The Haystack library integrated with the ElasticSearch engine was used to implement a google-like search i.e. single auto-complete search box that provides fast results and filters.<br>Machado aims to be a modern object-relational framework that uses the latests Python libraries to produce an effective open source resource for genomics research.