Global colorectal cancer gene expression in rats

The rat models of colorectal cancer (CRC), such as the azoxymethane (AOM) cancer-inducing model, are important tools for researching cancer initiation pathways. However, there is limited understanding of the expression pathways of underlying normal rat colonic epithelium and how this relates to human colonic epithelium. The aim of this study was to study the acute effects of AOM on the gene and pathway expression of the rat's colonic epithelium, whilst contrasting the background normal global expression patterns along the length of the rat as compared to the normal human colonic epithelium.结直肠癌（colorectal cancer, CRC）大鼠模型（如氧化偶氮甲烷（azoxymethane, AOM）致癌模型）是探究癌症起始通路的重要实验工具。然而，当前学界对正常大鼠结肠上皮的固有表达通路，及其与人类结肠上皮的关联机制仍缺乏足够认知。本研究旨在分析氧化偶氮甲烷对大鼠结肠上皮基因及通路表达的急性影响，并对比大鼠全结肠段的本底正常全局表达模式与人类正常结肠上皮的表达特征。