Temporal gene expression signature of plasma extracellular vesicles-miRNAs from post-smolt coho salmon challenged with Piscirickettsia salmonis

Piscirickettsiosis, is the most important bacterial disease in the Chilean salmon industry, that has sorted several efforts to its control, generating enormous economic losses. Cells use extracellular vesicles (EVs) as an inter-cellular communicator, to deliver several factors (e.g., microRNAs) that may regulate the responses of other cells. It is known that microRNAs (miRNAs) have relevant functional roles in the orchestration of adequate immune responses. However, there are a limited knowing about the identification and characterization of EV-miRNAs in salmonids or the effect of infections on these. In this study, we utilized Illumina sequencing technology to identify Coho salmon plasma EV-miRNAs upon P. salmonis infection at four different time points.