DataSheet_1_Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women.zip

Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher’s exact tests and the OS by Kaplan–Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (≥60 years) (1.84) compared with younger (≤40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexity.

在阿根廷、巴西、智利、墨西哥和乌拉圭五个拉丁美洲国家，对女性乳腺癌的分子图谱进行了研究。描述了社会经济特征、风险因素、预后因素和分子亚型，并估计了60个月的总累积生存概率（OS）。2011年至2013年间，邀请了1300名符合条件的18岁及以上拉丁美洲女性参与一项前瞻性队列研究，这些女性在临床分期为II或III期，且表现状态不大于等于1。进行了面对面访谈，并从病历中提取了临床和结果数据，包括死亡情况。未调整的关联性通过卡方检验和Fisher确切检验进行评估，而OS则通过Kaplan-Meier方法进行评估。使用Log-rank检验确定累积概率曲线之间的差异。通过在Cox回归模型中输入潜在的混杂因素，进行了多变量调整。60个月时的OS为83.9%。与墨西哥女性相比，在阿根廷（2.27）、智利（1.95）和乌拉圭（2.42）生活的女性的多变量调整后的死亡风险差异被发现，与年龄较大的（≥60岁）女性（1.84）相比，年龄较小的（≤40岁）女性，与基底样亚型（5.8）、luminal B（2.43）和HER2富集型（2.52）相比，与luminal A亚型，以及与IIB期（1.91）、IIIA期（3.54）和IIIB期（3.94）相比，肿瘤的临床分期IIA期女性的OS相关。OS与居住国家、PAM50内在亚型、年龄和诊断时的肿瘤分期相关。虽然后者已知受医疗保健的获取影响，包括癌症筛查、及时诊断和治疗，包括获得更有效的治疗方案，但它也可能影响表观遗传变化，这些变化可能影响分子亚型。来自以往研究较少的、具有独特地理血统和社会文化体验的人群的数据，对于进一步深化我们对这种复杂性的理解至关重要。