Since the advent of large-scale genomic sequencing, and the consequent availability of large numbers of homologous protein sequences, there has been burgeoning development of methods for extracting fu
The percent of sites with evidence for pervasive and episodic selection are reported for all ACE2 sites and spike binding sites when sites within ACE2 are not restricted to surface, extracellular site
Functional residues in proteins tend to be highly conserved over evolutionary time. However, to what extent functional sites impose evolutionary constraints on nearby or even more distant residues is
Average side-chain weighted contact number (SC-WCN) and distance to the protein center as well as average conservation gradient of the different types of functional sites.
