Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury

To investigate the effects of cardiomyocyte redifferentiation and its cardioprotective effects, we performed gene expression profiling analysis using data obtained from RNA-seq of whole hearts that were either WT, or ERBB2 over-expressing, at 3 different timepoints both for sham injury and MI injury. Overall design: Comparative gene expression profiling analysis of RNA-seq data for hearts either during (T1/Dediff), 2 weeks after (T2/Intermediate) or 4 weeks after (T3/Rediff) transient ERBB2 overexpression in cardiomyocytes, controlled for injury status and transgene presence.