Serotonin Gates Hippocampal VIP Interneuron Activation in Novelty Detection via Dual-Transmitter MnR Signaling

We sequenced thirteen vasoactive intestinal peptide (VIP)-expressing interneurons from the mouse CA1 oriens/alveus area using patch-seq technique to determine their molecular identity. Six neurons were recorded using patch-clamp technique, filled with biocytin for morphological identification and aspirated for next-generation sequencing. We also reanalyzed seven neurons from our previos dataset (GSM2966346-GSN2966352, GSE109755). The new analysis has focussed on the expression levels of the Htr genes. A total of 11 VIP-eGFP mice of either sex were used for these experiments. *************************************************************** The table below lists GEO accessions reused/reanalyzed for this study. ***************************************************************