RNA-Seq and protein mass spectrometry in microdissected kidney tubules reveal signaling processes initiating lithium-induced nephrogenic diabetes insipidus

Results and conclusion: Integration of new data with prior data about lithium effects at a molecular level leads to a signaling model in which lithium increases ERK activation leading to induction of NF-κB signaling and an inflammatory-like response that represses Aqp2 gene transcription.结果与结论：将新数据与既往关于锂在分子水平上的作用的相关数据整合后，可得到一套信号通路模型。该模型显示，锂可增强细胞外调节蛋白激酶（ERK）的激活，进而诱导核因子κB（NF-κB）信号通路活化并引发类炎症应答，该应答可抑制水通道蛋白2（Aqp2）基因的转录。