A novel kinase inhibitor for b-catenin mutant hepatocellular carcinoma [Cut&Run]
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE213515
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We screened HCC organoids to identify a CTNNB1-mutant HCC selective small molecule (WNTinib), with MOA depending on reactivation of cytoplasmic EZH2, leading to its nuclear translocation and selective transcriptional block of WNT targets Comparative Cut and Run analysis of H3K27me3-binding sites for MYC-CTNNB1 organoids +/- WNTinib vs MYC-Tp53 organoids +/- WNTinib, at 2 timepoints (+DMSO)
创建时间：
2024-04-02
