Wdr19

Acts upstream of or within several processes, including chordate embryonic development; embryonic organ development; and myotome development. Located in motile cilium and photoreceptor connecting cilium. Part of intraciliary transport particle A. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver; and lung. Used to study ciliopathy. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; asphyxiating thoracic dystrophy 5; cranioectodermal dysplasia 4; and nephronophthisis 13. Orthologous to human WDR19 (WD repeat domain 19). [provided by Alliance of Genome Resources, Nov 2024]

此基因在多个生物过程中发挥上游作用或位于其中，包括脊椎动物胚胎发育；胚胎器官发育；以及肌节发育。定位于能动纤毛和光感受器连接纤毛中。是内纤毛运输颗粒A的组成部分。在包括消化系统；泌尿生殖系统；血淋巴腺体；肝脏；以及肺等结构中表达。用于研究纤毛病。该基因的人类同源基因与多种疾病有关，包括卡洛里病；赛尼-洛克恩综合征；窒息性胸壁营养不良症5型；颅面外胚层发育不全4型；以及肾小管硬化症13型。与人类WDR19（WD重复结构域19）同源。[由基因组资源联盟提供，2024年11月]