LRmeth: a logistic regression approach for inferring tissue of origin from tumor DNA methylation profiles

LRmeth is a novel framework to infer a tumor's tissue of origin using DNA methylation profiles. This dataset accompanies the LRmeth manuscript and contains information about the CpGs used in this study. All CpGs come from the Illumina 450K array, and this study largely restricted the number of CpGs to the top 1% most variable positions across 12 different tumor types. DMPs.zip -- contains .tsv.gz files of the differential methylation results by tissue. Each CpG is also annotated with the nearest gene name and genic feature. healthy_markers.zip -- contains .tsv.gz files of healthy marker CpGs by tissue. Each CpG is also annotated with the nearest gene name and genic feature. high_variance_cpgs.txt -- a plain text file of the 2921 high-variance CpGs used in this study.