Reference TCR sequencing data for: "Identification of a TCR signature in peripheral blood derived CD4+ T cells, associated with chronic chikungunya disease (CCD), suggests a conducive, female-biased, background immune profile".

Abstract: To gain further insight into the physiopathology of CCD and to further the understanding of CD4+ T cell involvement we aimed to examine association of a specific TCR repertoire with CCD. To this end, we determined the TCR repertoire in bulk purified CD4+ T cells derived from peripheral blood from participants that did, or did not, progress to CCD, 6 months after confirmed infection during the 2020 CHIKV outbreak in Cambodia 34. TCR clustering and regression analyses allowed identification of CD4+ TCR signatures specifically associated with non-chronic or chronic patients. A noted preferential presence of the TCR signature associated with chronic disease in female participants further suggests a gender-biased immune profile conducive to progression to CCD. Together these findings further support a role for CD4+ T cells in the etiology and pathophysiology of CCD and suggest candidate biomarkers that may predict susceptibility for developing chronic symptoms following CHIKV infection. DOI of the related publication: 10.3389/fimmu.2026.1739100