Genome-wide gene expression analysis of hNAC1-dependent time course rescue of Nac1 null abnormal reprogrammed cells

In this study, we dissected the functional contribution of NAC1 in establishing pluripotency during somatic cell reprogramming. We identified a critical role for NAC1 in transcriptionally and post-transcriptionally modulating E-cadherin expression during the generation of iPSCs. In the absence of NAC1 functions, reprogramming is diverted to an anomalous state that can be fully rescued with the re-expression of Nac1. This study containes 6 microarrays from day 0, 2, and 5 samples of the hNAC1 time course rescue experiments from two in-house generated null iPS lines: Nac1 null iPS clone #5 and Nac1 null iPS clone #7