Pasteurellaceae bacterium NI1060 Genome sequencing and assembly

NI1060 is a murine bacterial pathobiont responsible for Nod1-dependent induction of periodontitis. To better understand its pathogenicity, we have fully sequenced its genome. We found genes encoding putative virulence factors including specific lipooligosaccharides, adhesins and bacteriotoxic proteins. These genes are potentially important for host adaption and for the induction of dysbiosis through bacterial competition and pathogenicity. Importantly, NI1060 possesses frameshift mutations in two genes that are important for peptidoglycan recycling. In addition, NI1060 is a novel species of the Pasteurellaceae family, closely related to P. pneumotropica, containing metabolic pathways that support growth from unique energy sources. Detailed analysis of it genome will be insightful for the development of NI1060 as a prime model system for infectious disease.