miR-93 microRNA binds PTEN mRNA
收藏reactome.org2025-03-25 收录
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MicroRNA miR-93-5p, one of the two mature products of miR-93, binds the 3'UTR of PTEN mRNA (Poliseno et al. 2010). miR-93 causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-93 also functions as a part of the nonendonucleolytic RISC.
MicroRNA miR-93-5p,作为miR-93的两个成熟产物之一,能够与PTEN mRNA(3'非翻译区)结合(Poliseno等人,2010年)。miR-93能够导致PTEN mRNA及蛋白水平的降低,从而证实其作为内切核酸酶RISC(RNA干扰沉默复合物)功能组分的作用。此外,miR-93亦有可能作为非内切核酸酶RISC的功能组分。
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