Small RNA Sequencing in Polytrauma Patients: High vs. Low Troponin T Levels

In this study, small RNA sequencing was performed on plasma samples from 10 polytraumatized patients (Injury Severity Score, ISS = 16), who were stratified into two groups based on their initial Troponin T (TnT) levels at the emergency room. The high TnT group (n = 5) included patients with TnT concentrations > 50 pg/mL, while the low TnT group (n = 5) included those with TnT concentrations < 12 pg/mL. The aim of this dataset is to identify differentially expressed miRNAs associated with elevated TnT levels, a marker of cardiac injury in trauma patients. Differential expression analysis revealed several candidate miRNAs that may serve as potential biomarkers for cardiac dysfunction. This dataset highlights the diagnostic potential of miRNAs in post-trauma cardiac injury. Overall design: Small RNA sequencing profiling of plasma samples from polytraumatized patients stratified into high- and low-Troponin T groups to identify miRNAs associated with cardiac injury.