Differential gene expression due to full trisomy, attributable specifically to Erg trisomy, and trisomy of non-Erg genes.

Differential gene expression with the number of up-regulated and down-regulated probes (False discovery rate (FDR) of 0.05, NS = not significant), as a consequence of full trisomy (pairwise comparison Ts65Dn/Erg+/+/+ versus Erg+/+), trisomy of Erg (Ts65Dn/Erg+/+/+ versus Ts65Dn/Erg+/+/Mld2) and non-Erg gene trisomy (Ts65Dn/Erg+/+/Mld2 versus Erg+/+) in LSK, CMP, GMP and MEP hematopoietic cells (see [20], Fig 1A and S2 Table). Three biological replicates per cell type per genotype were obtained using pooled RNA derived from 2–4 mice (including male and female) per genotype per replicate, for a total of 48 arrays.Differential gene expression due to full trisomy, attributable specifically to Erg trisomy, and trisomy of non-Erg genes.