Rapid simulation framework integrating MRI-derived synthetic CT for precise transcranial focused ultrasound targeting

Accurate targeting is critical for the effectiveness of transcranial focused ultrasound (tFUS) neuromodulation. While CT provides accurate skull acoustic properties, its ionizing radiation and poor soft tissue contrast limit clinical applicability. In contrast, MRI offers superior neuroanatomical visualization without radiation exposure but lacks skull property mapping. This study proposes a novel, fully CT-free simulation framework that integrates MRI-derived synthetic CT (sCT) with efficient modeling techniques for rapid and precise tFUS targeting. We trained a deep-learning model to generate sCT from T1-weighted MRI and integrated it with both full-wave (k-Wave) and accelerated simulation methods—hybrid angular spectrum (kW-ASM) and Rayleigh-Sommerfeld ASM (RS-ASM). Across five skull models, both full-wave and hybrid pipelines using sCT demonstrated sub-millimeter targeting deviation, focal shape consistency (FWHM ~3.3-3.8 mm), and 1270) to (187±27) and (345±85) s respectively, achieving ~94% and ~90% time savings. These results confirm that MRI-derived sCT combined with innovative rapid simulation techniques enables fast, accurate, and radiation-free tFUS planning, supporting its feasibility for scalable clinical applications.