Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation

We systemetically distinguished the effects of each class of sex-biasing factors on transcriptome regulation in liver and adipose tissues with the Four Core Genotype (FCG) mouse model. The results offers a tissue-specific account of the individual contribution of major sex-biasing factors to gene regulation. We utilized the Four Core Genotype (FCG) mouse model with or without hormone replacement to distinguish the effects of each class of sex-biasing factors on transcriptome regulation (e.g., gene expression, molecular pathways, gene network organizations, etc.) in liver and adipose tissue.