Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis

NIAID Data Ecosystem2026-03-13 收录

肌萎缩侧索硬化

RNA剪接异常

数据链接：

https://data.mendeley.com/datasets/v7p6dh5tvc 数据链接链接失效反馈

官方服务：

资源简介：

This dataset contains data related to Krach et al., Acta Neuropathologica, 2022, DOI: 10.1007/s00401-022-02450-3

创建时间：

2022-06-29

1218例肌萎缩侧索硬化患者糖尿病患病率的临床研究

肌萎缩侧索硬化

糖尿病

研究背景：肌萎缩侧索硬化(Amyotrophic lateral sclerosis，ALS)是累及上、下运动神经元的神经退行性疾病。代谢性疾病特别是糖尿病与ALS有多种关系。既往研究提示与一般人群相比，ALS患者的糖尿病患病率较低。多数研究认为糖尿病与ALS患者生存率无关，但发病时间延迟。北京协和医院是国内较大的ALS诊治中心之一。本研究拟通过对北京协和医院ALS队列进行分析，并与既往研究数据对

中国科学院中国科学技术大学科学数据中心260

Integrative proteome analyses implicate aberrant RNA splicing impairs developmental potential of aged mouse oocytes

卵母细胞衰老

RNA剪接异常

Aging has many effects on female reproductive system, among which declined oocyte quality and impaired embryo developmental potential are the most important factors affecting female fertility. However

NIAID Data Ecosystem30

Disrupted minor intron splicing activates reductive carboxylation-mediated lipogenesis to drive metabolic dysfunctionâassociated steatotic liver disease progression

代谢疾病机制

RNA剪接异常

Aberrant RNA splicing is tightly linked to diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we revealed that minor intron splicing, a unique and conserved RN

NIAID Data Ecosystem10

RNA Splicing Factor Retinitis Pigmentosa. Mus musculus strain:129SV

视网膜色素变性

RNA剪接异常

Inherited retinal degenerations (IRDs) are important causes of blindness that are characterized by progressive dysfunction and death of rod and cone photoreceptor cells leading to vision loss. Mutatio

NIAID Data Ecosystem40

RNA mis-splicing sensitizes SETD2-mutant kidney cancer cells to DNMTi (ChiP-Seq and RNA-Seq). RNA mis-splicing sensitizes SETD2-mutant kidney cancer cells to DNMTi (ChiP-Seq and RNA-Seq)

癌症表观遗传学

RNA剪接异常

The dysregulation of the histone H3 lysine 36 (H3K36) methyltransferase, SETD2, is associated with worse clinical outcomes and metastasis in clear cell Renal Cell Carcinoma (ccRCC). Here, we reveal th

NIAID Data Ecosystem20

Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis

资源简介：

相关数据集